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Phases | MonoTip-TiO

MonoTip TiO2 Titanium Dioxide Pipette Tips Highly Selective Enrichment of phosphorylated peptides from complex peptide mixtures      Extremely selective for phosphorylated peptide extraction and/or enrichment from proteolytic digests    More selective than IMAC for most applications    ATiO2 coated monolith disk provides better flow properties than packed-bed pipette tips A completely new base material for low pressure, pipette-tip enrichment of phosphorylated peptides has been developed by GL Sciences. This unique material consists of Titanium Dioxide coated on the surface of a porous silica monolithic disc, which is immobilized in a pipette tip. Tips are available in standard 10-200uL size in packages of 8 or 96. MonoTip TiO2 offers greater selectivity for phosphopeptides than alternative methods, such as IMAC (immobilized metal affinity chromatography). Typically, IMAC shows significant binding of non-phosphorylated peptides which have multiple acidic residues. This problem is often eliminated by using MonoTip TiO2.